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Year : 2019  |  Volume : 68  |  Issue : 3  |  Page : 196-200

Histopathological and Histomorphometric studies on the effects of Olanzapine on Testis: An experimental study in Albino Rats

Department of Anatomy, Jawaharlal Nehru Medical College and Hospital, AMU, Aligarh, Uttar Pradesh, India

Correspondence Address:
Dr. Masooma Syed
Department of Anatomy, Jawaharlal Nehru Medical College, AMU, Aligarh - 202 001, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JASI.JASI_43_19

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Introduction: Toxic effects of an antipsychotic drug on male gonad were explored experimentally. Olanzapine, an antipsychotic drug, has affinity for a wide range of receptors posing danger to the large variety of organs. Since olanzapine can bind to these receptors, a direct effect of these drugs on spermatogenesis is possible. Therefore testis, an organ least attended, has been selected in the present study. Material and Methods: Two groups of animals of the equal number were designed in such a way that the first group acted as control and second group acted as experimental. After histopathological comparison in the tissue of the testis, histomorphometric analysis was also performed to support the former. Twelve albino male rats were divided into two groups of six animals each. Olanzapine was injected in experimental rats in a dose of 4 mg/kg body weight intraperitoneally for 6 weeks. Sections of both experimental and control testis were examined under light microscope for histopathological findings. Histomorphometric informations were also collected to support the former findings by using ocular and stage micrometers. Student's t-test was used to compare the control testis findings with the single variable experimental one. Results: Experimental testis showed intra and interlobular edema, compressed seminiferous tubules, thinning and fragmentation of basement membrane. Spermatogenic cells were smudgy and compressed by edema fluid. Blood vessels showed inflammatory cells in the lumen. Discussion and Conclusion: Olanzapine-induced testicular degeneration might lead to reduced libido, a fact of great social impact.

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