|Year : 2019 | Volume
| Issue : 1 | Page : 39-45
Retrospective analysis of adult thoracic surface anatomy in Indian population using computed tomography scans
Shallu Garg1, Ajay Gulati2, Anjali Aggarwal1, Tulika Gupta1, S Ali Mirjalili3, Daisy Sahni1
1 Department of Anatomy, Postgraduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India
3 Department of Anatomy and Medical Imaging, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
|Date of Web Publication||16-Jul-2019|
Dr. Anjali Aggarwal
Department of Anatomy, Postgraduate Institute of Medical Education and Research, Chandigarh - 160 012
Source of Support: None, Conflict of Interest: None
Introduction: Recent studies on human surface anatomy observed inconsistencies in standard surface markings from that given in contemporary anatomy texts, particularly in thoracic surface landmarks. The present study was conducted to reevaluate the thoracic surface anatomy of adults of Indian origin which has not been done so far and compare the observations with the descriptions obtained from other population groups. Material and Methods: The thoracic surface anatomy was analyzed in 100 thoracoabdominal computed tomography scans of the Indian population. Results: It was observed that the positions of the xiphisternal joint, sternal angle, central veins, apex of lungs, cardiac apex, and dome of the diaphragm were within the normal limits with slight deviations from that described in standard anatomy texts. However, certain landmarks showed high degree of difference among the races as well as from the descriptions of the textbooks such aortic arch, bifurcations of the trachea and pulmonary trunk, inferior border of right and left lung adjacent to the vertebral column, and vertebral level of inferior vena cava piercing the diaphragm. Discussion and Conclusion: The surface anatomical landmarks of the thorax are not static, and there is a need to accommodate for a range of values than the constant markings. The relationship of the thoracic structures with the overlying surface landmarks were more variable in relation to vertebral levels than the costal references.
Keywords: Cardiac apex, central veins, diaphragm, lungs, sternal angle
|How to cite this article:|
Garg S, Gulati A, Aggarwal A, Gupta T, Mirjalili S A, Sahni D. Retrospective analysis of adult thoracic surface anatomy in Indian population using computed tomography scans. J Anat Soc India 2019;68:39-45
|How to cite this URL:|
Garg S, Gulati A, Aggarwal A, Gupta T, Mirjalili S A, Sahni D. Retrospective analysis of adult thoracic surface anatomy in Indian population using computed tomography scans. J Anat Soc India [serial online] 2019 [cited 2019 Oct 16];68:39-45. Available from: http://www.jasi.org.in/text.asp?2019/68/1/39/262715
| Introduction|| |
Surface anatomy defines the relationship of the surface landmarks to the underlying deeper structures. To locate the anatomical structures under the skin with reference to palpable surface features is a core clinical skill, precise understanding of which is invaluable in the clinical assessment of a patient, in interventional procedures, and in the interpretation of radiological imaging.
Surface anatomy and surface markings are integral components of medical curriculum, aims at preparing students for clinical examination of patients  and provide important bridges between the laboratory and the clinic. Surface anatomy is certainly of value in helping students learn human anatomy as shown by the success of body painting as a learning tool. Given the importance of surface anatomy, educational resources need to be more consistent. Our current understanding on this topic is largely derived from the cadaveric studies and measurements recorded decades ago, with all the limitations of distortion from embalming and positioning. Recent studies on human surface anatomy in different races using modern cross-sectional imaging techniques have documented major inconsistencies in standard surface markings from that given in contemporary anatomy texts.,,,, According to their findings, although many surface landmarks are valid, however, variations with respect to age, sex, and particularly population were observed.
Knowledge of the surface anatomy of intrathoracic structures and the level of the diaphragm based on the surface landmarks is useful for interventional procedures, such as tube thoracostomy and for placing the thoracic incisions to provide the best access to the pulmonary hila, trachea, or great vessels. The present study was conducted to reevaluate the thoracic surface anatomy of adults of Indian origin which has not been done so far and compare the observations with the descriptions obtained from other population groups.
| Material and Methods|| |
One hundred thoracoabdominal computed tomography (CT) scans (66 males and 34 females) with the mean age of the patients 45.7 years, (range 20–80 years) performed in the Department of Radiology of our institute for various clinical indications were analyzed to determine the thoracic surface anatomy. All patients were of Indian origin. The CT examinations were performed on 128-MDCT dual-source scanner (Somatom Definition Flash, Siemens Healthcare, and Germany). The following technical parameters were used: pitch – 0.6, gantry rotation time - 0.5 seconds, and thickness of 5 mm. Scans of patients were acquired with intravenous contrast in the supine position, at end-tidal inspiration and with the arms abducted. The dose of intravenous contrast medium was calculated according to the patient's physical characteristics and clinical condition. CT postprocessing of data and image reconstructions was performed on dedicated workstation (Syngo Multimodality Workplace 2008A; Siemens). Scans of patients with kyphosis, scoliosis, abnormal lordosis, distorting space-occupying, and organomegaly were excluded from the analysis. Plane of sternal angle and xiphisternal joint with respect to vertebrae were assessed. Positions of important intrathoracic structures in relation to commonly practiced surface landmarks such as sternal angle and vertebrae, costal cartilage (CC), sternocostal joint, and clavicle were also studied as shown in [Figure 1].
|Figure 1: Computed tomography images showing (a) Vertebral level of the sternal angle (T5) identified in sagittal scan. (b) Vertebral level at which the esophagus and aorta passed through or behind the diaphragm determined in sagittal projections. (c) Pulmonary trunk bifurcation identified in axial scans. (d) Carina of tracheal bifurcation identified in coronal scans. (T, Thoracic vertebra)|
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Means and standard deviations were calculated for continuous data. Comparisons between groups/measurements (i.e., left versus right, male versus female) were made using a paired-sample and independent-sample t-test, respectively. P < 0.05 indicated a statistically significant difference. The association between collected measurements and age were tested using a Pearson's correlation test.
This study was approved by the Institutional Ethics Committee (No: NK/3654/Study/561).
| Results|| |
Sternal angle and its relationship to associated structures
The distribution of frequencies of vertebral levels of sternal angle, tracheal bifurcation, azygous vein/superior vena cava junction (azygos/SVC junction), pulmonary trunk bifurcation, and summit of aortic arch and xiphisternal joint, in all the 100 scans, is shown in [Figure 2].
|Figure 2: Frequency of distribution of vertebral levels of (a) Sternal angle. (b) Tracheal bifurcation. (c) Azygos/superior vena cava junction. (d) Pulmonary trunk bifurcation. (e) Summit of aortic arch. (f) Xiphisternal joint. X-axis represents vertebral level and Y-axis represents the frequency (U: Upper, L: Lower,/: Intervertebral disc, T: Thoracic vertebra)|
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Analysis of data revealed that the vertebral plane of sternal angle varied widely from T3/4 to T6/7 intervertebral disc, though the most common vertebral level of the sternal plane was T4/5 intervertebral disc (35% of adults). However, it was observed that in >two-third of cases (82%), the plane of angle was between T4/5 and T5/6 intervertebral disc. Likewise, two more structures, the tracheal bifurcation and the azygos/SVC junction, were also lying between T4/5 and T5/6 intervertebral disc in 72% and 71% cases, respectively. There were no statistically significant gender differences in the observations (P > 0.05).
Vertebral plane of summit of the concavity of aortic arch too showed a wide variation from upper T2 (UT2) to T4/5 intervertebral disc. However, the most common vertebral level of aortic arch was T3/4 intervertebral disc (41%). Similarly, the vertebral level of pulmonary trunk bifurcation ranged from T3/4 to lower T7 (LT7), although in 58% adults, it was lying between T5/6 intervertebral disc to UT6 [Figure 2].
The exact relation of tracheal bifurcation, aortic arch, azygos/SVC junction, and pulmonary trunk bifurcation to the sternal plane are presented in [Table 1]. The concavity of the aortic arch was above the sternal plane in most of the cases (89%, P < 0.0001) at a mean distance of 3.05 ± 1.74 cm and pulmonary trunk bifurcation was lying more commonly below the sternal plane (73%, P < 0.0001) at an average distance of 1.95 ± 1.64 cm below the sternal plane. Within 10 mm of sternal plane, the tracheal bifurcation was present in 46%, termination of the azygos vein into the SVC in 62% and pulmonary trunk bifurcation in 32% of scans. Vertebral level of sternal angle was positively correlated with the tracheal bifurcation (r = 0.521; P = 0.001) and pulmonary trunk bifurcation (r = 0.597; P = 0.001).
|Table 1: Relationship between the sternal angle and the major anatomical structures|
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The distribution of vertebral level of the xiphisternal joint is depicted in [Figure 2]f. The horizontal plane through the xiphisternal joint most commonly extended from T8/9 intervertebral disc to T9/10 intervertebral disc (64%) in both males and females.
The origin of the brachiocephalic vein (BCV) in relation to ipsilateral sternoclavicular joint was most commonly lying behind the joint (48% on the right and 58.6% on the left) or lateral (43.8% on the right and 34.6% on the left) to the joint, with no significant gender differences. The distribution of cranial and caudal levels of SVC in reference to CCs and anterior intercostal spaces (ICS) is shown in [Figure 3]a and [Figure 3]b. Formation of SVC (cranial end of SVC) was mainly lying behind the first right CC and first ICS in 86% of adults and was partially overlapped by manubrium in 71% of scans. The SVC/right atrial junction (SVC/RA junction; caudal end of SVC) most commonly extended from the right third CC to 4th CC in 79% of adults. There were no significant gender differences in SVC origin (P = 0.65) or the SCV/RA junction (P = 0.81).
|Figure 3: Frequency of distribution in reference to costal cartilage and intercostal space of the (a) Formation of superior vena cava. (b) Superior vena cava /Right atrial junction. (c) Cardiac apex|
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The position of the cardiac apex varied from 4th to 6th rib. It was at the level of 5th rib (49%) or 5th ICS (20%) anteriorly in maximum number of cases [Figure 3]c. The cardiac apex was positioned on an average 7.72 ± 1.37 cm to the left of midline (range 4.56–10.62 cm). There were no significant gender or age differences.
The apex of the right lung was lying posterior to the medial third of the clavicle in 56 scans (with 22% crossing above the clavicle at a mean distance of 1.57 cm) and medial end of the clavicle in 40 scans (with 18% crossing above the clavicle at a mean distance of 1.27 cm). Similarly, the apex of the left lung was lying posterior to the medial third of the clavicle in 52 scans (with 20% crossing above the clavicle at a mean distance of 2.38 cm) and medial end of the clavicle in 32 scans (with 19% crossing above the clavicle at a mean distance of 1.56 cm). The anterior inferior border of the lung in midclavicular line was most commonly at the level of 6th rib (32, 51.6%) on the right and 6th rib (29, 46.7%)/7th rib (23, 37%) on the left [Figure 4]a. The anterior inferior border of the right lung was higher than the left lung in both males and females. The level of the posterior inferior border of both the lungs adjacent to the vertebral column ranged from T9/10 intervertebral disc to T12/L1 intervertebral disc. It was most commonly alongside the T11/12 intervertebral disc followed by T12 intervertebral disc in both the lungs [Figure 4]b. There were no significant gender and age differences.
|Figure 4: Frequency of distribution of (a) Costal level of anterior inferior border of the right and left lung at the level of midclavicular line. (b) Vertebral level of posterior inferior border of the right and left lung adjacent to the vertebral column. (ICS: Intercostal space, U: Upper, L: Lower, /: Intervertebral disc)|
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The costal level of the summit of dome of the diaphragm ranged from 3rd to 6th rib on the right side and 4th to 6th rib on the left side. On the right side, the dome was most commonly at the level of 5th rib (29%) followed by 4th rib (19%), and on the left, it was lying one rib lower, at the level of 5th rib in 40% and 6th rib in 24% of cases [Figure 5]a.
|Figure 5: Frequency of distribution of (a) Costal level of the summit of dome of the diaphragm. (b) Vertebral level of passage of IVC, esophagus, and aorta through/behind the diaphragm. (ICS: Intercostal space, U: Upper, L: Lower, /: Intervertebral disc, IVC: Inferior vena cava)|
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[Figure 5]b illustrates the vertebral levels at which three main structures: inferior vena cava (IVC), esophagus, and aorta traversed through the diaphragm. The level of IVC varied from as high as UT7 vertebra to T11/12 intervertebral disc; however, most commonly it traversed through the diaphragm at the level of T9/10 intervertebral disc (26%) in both males and females. The esophagus and aorta traversed most commonly at T10/11 intervertebral disc (32%) and T11/12 intervertebral disc (41%) respectively.
Correlation with age
There was a positive correlation between age and surface anatomy of sternal angle (r = 0.94; P = 0.05), cranial (r = 0.547; P = 0.03) and caudal levels of SVC (r = 0.519; P = 0.04) [Table 2].
|Table 2: Age-related changes in the surface anatomy of sternal angle and superior vena cava|
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| Discussion|| |
The observations of the present study differed from that reported in other population studies [Table 3], [Table 4], [Table 5], though the surface anatomy in reference to costal skeleton was strikingly congruent with the textbook description [Table 4].
|Table 3: Vertebral level of various thoracic structures and their relation with sternal angle in different populations|
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|Table 4: The costal level of various thoracic structures in different populations|
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The vertebral level of the sternal plane in different population studies was most commonly intersecting the T4 vertebra or T4/5 intervertebral disc coinciding with the anatomy textbooks [Table 3]. In our study, the vertebral level of the sternal angle was seen to change with age. In the early decades of life, the level coincided with the anatomical texts; however, with each increasing decade, slight downward shift was observed. Similar trend was noticed in the Chinese population.
According to most of the studies, the tracheal bifurcation, aortic arch, azygos/SVC junction, and pulmonary trunk bifurcation lie below the level of the sternal plane. In our study of the Indian population, the azygos/SVC junction was lying most commonly at the level of sternal angle, although its position varied from 2.8 cm above to 2.6 cm below the sternal plane. Tracheal bifurcation and pulmonary trunk were lying most commonly below the sternal plane. Similar observations have been reported in the African population  [Table 3].
According to major anatomy texts,,, the vertebral level at which the IVC, esophagus, and aorta pass through/behind the diaphragm is T8, T10, T12 vertebra, respectively, indicating difference of two vertebrae between these structures. Observations of the present and all the other studies have depicted that the vertebral level at which the IVC, esophagus, and aorta pass through/behind the diaphragm were most commonly one vertebra down relative to each other and most commonly at the level of T10, 11, and 12 vertebra, respectively. Xiphisternum lies at the level of T8/9–T9 vertebra in all the population studies [Table 3].
The right and left BCVs of the Indian population was located directly posterior to the ipsilateral sternoclavicular joint similar to that recorded in Iranian  and European  populations and confirming the descriptions given in medical texts.,, In contrast, in the South African  and Chinese  population, it was located superolateral or lateral to the ipsilateral sternoclavicular joint. There were no gender related differences in the present and the previous populations.
The surface anatomy of the cranial and caudal end of SVC in reference to costal skeleton was congruent with the text book description in the Indian and South African population  but differed from that reported in other population studies [Table 4]. The SVC/RA junction was age related in our population and that of Chinese population. There were no gender-related differences in both the levels, in the Indian and other population studies except that SVC/RA junction was significantly higher in females of European population.
In most of the population studies, cardiac apex was most commonly located at 5th ICS which is congruent to the medical texts [Table 4]. However, in the present study (Indian population), cardiac apex was located mostly at 5th rib followed by 5th ICS and was more toward the midline (77 ± 13.7 mm to the left of midline) than the other population studied, including African  (81.3 ± 12.8 mm), Chinese  (83 mm), and European  (87 ± 10 mm) populations.
In the present population, the dome of the diaphragm at end-tidal inspiration in the supine position was at 5th rib or 5th ICS on the right and 5th or 6th rib on the left, comparable to the anatomy texts [Table 4]. In contrast, in the European population, the dome was slightly lower at the level of 5th ICS on the right and 6th rib on the left.
The apex of the lung was most commonly posterior to the medial third of the clavicle in the Indian and European populations which is in agreement with the common medical textbooks [Table 5]. The surface marking of the inferior border of the lung in quiet respiration is represented by a line passing through the 6th rib inthe midclavicular line, the 8th rib in the midaxillary line, 10th rib at the scapular line, and T10 vertebra posteriorly.,, There are few studies mentioning surface marking of inferior border of the lung which according to the present findings, the rule of 6, 8, and 12 given by Mirjalili et al. would be more accurate than 6, 8, and 10 given in textbook descriptions.
| Conclusions|| |
From all these elaborative studies, it is confirmed that surface anatomical landmarks are not static and there isa need to accommodate for a range of values than the constant markings. Incorporating these findings into the texts would help clinicians to improve their clinical skills. There were no statistically significant gender differences found in the thoracic surface anatomy in the present population and most of the other population studies.
The authors would like to thank residents of the Department of Radiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, for their invaluable assistance with obtaining of CT scans.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
Standring S. Evidence-based surface anatomy. Clin Anat 2012;25:813-5.
Sayeed RA, Darling GE. Surface anatomy and surface landmarks for thoracic surgery. Thorac Surg Clin 2007;17:449-61.
Azer SA. Learning surface anatomy: Which learning approach is effective in an integrated PBL curriculum? Med Teach 2011;33:78-80.
McMenamin PG. Body painting as a tool in clinical anatomy teaching. Anat Sci Educ 2008;1:139-44.
Mirjalili SA, Hale SJ, Buckenham T, Wilson B, Stringer MD. A reappraisal of adult thoracic surface anatomy. Clin Anat 2012;25:827-34.
Shen XH, Su BY, Liu JJ, Zhang GM, Xue HD, Jin ZY, et al.
A reappraisal of adult thoracic and abdominal surface anatomy via CT scan in Chinese population. Clin Anat 2016;29:165-74.
Uzun C, Atman ED, Ustuner E, Mirjalili SA, Oztuna D, Esmer TS. Surface anatomy and anatomical planes in the adult Turkish population. Clin Anat 2016;29:183-90.
Pak N, Patel SG, Hashemi Taheri AP, Hashemi F, Eftekhari Vaghefi R, Naybandi Atashi S, et al.
A reappraisal of adult thoracic and abdominal surface anatomy in Iranians in vivo
using computed tomography. Clin Anat 2016;29:191-6.
Keough N, Mirjalili SA, Suleman FE, Lockhat ZI, van Schoor A. The thoracic surface anatomy of adult black South Africans: A reappraisal from CT scans. Clin Anat 2016;29:1018-24.
Moore KL, Dalley AF, Agur AM. Clinically Oriented Anatomy. 6th
ed. Philadelphia: Lippincott Williams and Wilkins; 2010. p. 1-1134.
Standring S. Gray's Anatomy: The Anatomical Basis of Clinical Practice. 41st
ed. London: Churchill Livingstone, Elsevier; 2015. p. 1-1584.
Sinnatamby CS. Last's Anatomy: Regional and Applied. 12th
ed. Edinburgh: Churchill Livingstone, Elsevier; 2011. p. 1-548.
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5]